Dental Hygiene & Oral Health Research

<center> # Dental Hygiene & Oral Health Research Originall published 2024-04-09 by Nick Sweeting on <a href="https://docs.sweeting.me/s/blog">docs.sweeting.me/s/blog</a>. 🦷 This is a list of the research I've collected in the crusade to have healthy teeth till I'm 90. 🦷 <hr/> </center> ## Probiotics ### The "Anti-Cavity Vaccine" (`BCS3-L1` / `A2JM`) - [Caries Vaccine | Wikipedia](https://en.wikipedia.org/wiki/Caries_vaccine?useskin=vector#Attempts_using_replacement_therapy) - [2005 Present and Future Approaches for the Control of Caries](https://onlinelibrary.wiley.com/doi/10.1002/j.0022-0337.2005.69.5.tb03941.x) - [2006 SEC filing for cavity vaccine company](https://ir.oragenics.com/all-sec-filings/content/0001193125-07-062141d10ksb.htm#:~:text=except%20that%20it%20requires%20exogenous%20D%2Dalanine%20for%20survival) ⭐️ - [2006 Modification of an effector strain for replacement therapy of dental caries to enable clinical safety trials. Journal of Applied Microbiology, 102\(5\), 1209–1219 | 10.1111/j.1365-2672.2007.03316.x](https://sci-hub.ru/10.1111/j.1365-2672.2007.03316.x) - [2007 Modification of an effector strain for replacement therapy of dental caries to enable clinical safety trials - PubMed](https://pubmed.ncbi.nlm.nih.gov/17448156/) - [2010 ‘Use a Thorn to Draw Thorn’ Replacement Therapy for Prevention of Dental Caries](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993818/) - [2011 Antibacterial Peptides: Opportunities for the Prevention and Treatment of Dental Caries](https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=161ce2d71511fa231cb851bcc211b0cf4ede108e) - [2018 Ecological Approaches to Dental Caries Prevention: Paradigm Shift or Shibboleth?](https://karger.com/cre/article/52/1-2/153/86192/Ecological-Approaches-to-Dental-Caries-Prevention) - [2020 Application of Antibiotics/Antimicrobial Agents on Dental Caries](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013294/) - [2023 A genetically modified bacterium that outcompetes bacteria causing tooth decay | Hacker News](https://news.ycombinator.com/item?id=38562939) - [2022 Effect of Probiotic Streptococcus salivarius K12 and M18 Lozenges on the Cariogram Parameters of Patients With High Caries Risk: A Randomised Control Trial](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012604/) - [2024 Hillman JD - Search Results - PubMed](https://pubmed.ncbi.nlm.nih.gov/?term=Hillman+JD&cauthor_id=12369203) - [2024 Thread by Crémieux \(Twitter @cremieuxrecueil\) about BCS3-L1](https://twitter.com/cremieuxrecueil/status/1777909941010899232) ### Companies / Products in the oral probiotic space - [Lantern Bioworks](https://www.lanternbioworks.com/) [Lantern | More info...](https://drive.google.com/drive/u/0/folders/18ZDSe92LgLmS0sUbosvNxByii_1kjnEj) / [Oragenics](https://www.oragenics.com/technology-pipeline/lantibiotics) - [Lumina Probiotic](https://www.luminaprobiotic.com/) ⭐️ - [ProBiora](https://probiorahealth.com/product/probiora/) - [FLORASSIST® Probiotic Oral Hygiene, 30 lozenges](https://www.lifeextension.com/vitamins-supplements/item02120/florassist-oral-hygiene) --- ## Mouthwashes - [2016 Fluoride mouthrinses for preventing dental caries in children and adolescents](https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD002284.pub2/full) - [2017 Chlorhexidine mouthrinse as an adjunctive treatment for gingival health](https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008676.pub2/full) ⭐️ --- ## Sugar Alcohols - [2013 Effect of three-year consumption of erythritol, xylitol and sorbitol candies on various plaque and salivary caries-related variables - PubMed](https://pubmed.ncbi.nlm.nih.gov/24095985/) - [2020 Xylitol and erythritol inhibit real-time biofilm formation of Streptococcus mutans - PubMed](https://pubmed.ncbi.nlm.nih.gov/32600259/) - [2020 Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries - PubMed](https://pubmed.ncbi.nlm.nih.gov/32286378/) - [XYLITOL: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews](https://www.webmd.com/vitamins/ai/ingredientmono-996/xylitol) --- ## Remineralization ### Recaldent (`CPP-ACP`) - https://en.wikipedia.org/wiki/Amorphous_calcium_phosphate - https://pubmed.ncbi.nlm.nih.gov/19717408/ - https://www.rdhmag.com/career-profession/personal-wellness/article/16405072/clinical-applications-of-recaldent-products - https://www.mountainside-medical.com/pages/what-is-recaldent-html - https://www.drbicuspid.com/dental-specialties/periodontics/article/15356516/wrigley-and-cadbury-clash-over-recaldent-gum - https://www.dentistryiq.com/dental-hygiene/student-hygiene/article/16368606/clinical-studies-demonstrate-the-benefit-of-chewing-sugar-free-gum-containing-recaldent-tm ### Calcium Sodium Phospho-Silicate Bioglass (`45S5`) - https://en.wikipedia.org/wiki/Bioglass_45S5 *more research needed...* ### Oligopeptide Peptide (`P11-4`) - https://en.wikipedia.org/wiki/Oligopeptide_P11-4 *more research needed...* --- ## Role of Genetics vs Behavior vs Micro-Biome - https://www.nidcr.nih.gov/news-events/nidcr-news/2019/genes-are-key-oral-health-beyond - https://www.ada.org/resources/ada-library/oral-health-topics/genetics-and-oral-health - https://www.sweetwatersmiles.com/blog/the-role-of-genetics-in-dental-health --- ## Other - [2023 Japan pharma startup to begin human trials of tooth regrowth drug in 2024 | Hacker News](https://news.ycombinator.com/item?id=37638956) - [2023 Japan pharma startup developing world-first drug to grow new teeth](https://english.kyodonews.net/news/2023/09/d56fb464a52b-japan-pharma-startup-developing-world-first-drug-to-grow-new-teeth.html)